Successful diffusion of a sound field in space relies on every loudspeaker being assigned correctly to each software rendered output channel.
A diffusion system could range from a simple pair of headphones to a 64 speaker array and anything in-between. In some of the more virtualised workflows of Spat Revolution, you may even be thinking about diffusion in a virtual space on configurations of virtual speaker arrangements and channel based formats. The same rule for successful diffusion applies here - the diffusion in the virtual room will be compromised and sound off, if the channel assignments to the virtual systems are incorrect.
In the above illustration a virtual 5.1 and a virtual Cube arrangement exist together in a High Order Ambisonic Room, which may eventually be rendered to some other channel based end format.